What is the current go-to citation for MOST?


The current go-to citation for MOST is: Collins, L.M. (2018), Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST). New York: Springer.

You can find a list of Recommended Reading on intervention optimization in the Recommended Reading section of this website. In general, it is best to be very careful if considering relying on or citing literature that appeared before about 2014. MOST was reconceptualized around that time, and continues to evolve rapidly. It is a good idea to check this website frequently for updates and to watch for the latest literature on intervention optimization.

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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