OK, I took your advice and read the preface and first chapter of Collins (2018). Do I now know enough to write a successful grant proposal based on MOST?


You almost certainly need some additional background before you can write a successful grant proposal. MOST is a very different way of thinking. If after reading the first chapter of Collins (2018) you have concluded that MOST will be useful to you in your work, we suggest you read the remainder of the book, followed by the readings in the Recommended Reading section of this website.

Intervention optimization is an active area of research, and the methodology is evolving rapidly.  We suggest you check this website often for updates.

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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