Free Software

Download free software to help you power a factorial optimization trial.

Recommended Reading

This section highlights a few implementations of MOST; provides readings that may be helpful in selecting an experimental design, conducting analyses from optimization trials, and implementing optimization trials; and lists recent articles on intervention optimization methods.

Frequently Asked Questions

This section clarifies some of the more common misconceptions about intervention optimization, factorial experiments, and more.

Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.


Here you will find recorded videos introducing MOST for different audiences – new investigators, biostatisticians, and reviewers.


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