Everything I have read about MOST, and all the presentations I have seen, treat the three phases as if they are all essential. Yet, I wonder whether it is always necessary to conduct an evaluation trial.


Recently, thinking has begun to change about this.  Some people working in the optimization methodology area agree that there are likely to be times when an evaluation trial is not needed.  The big and interesting question is how to go about deciding whether or not an evaluation trial is needed.  This is an active research area.

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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