I’ve conducted an optimization trial and analyzed the data. Now my team is going to use the results to optimize our intervention! I am excited but nervous. Do you have any advice?


This IS exciting!  Congratulations on having arrived at this point.  It took a lot of hard work to get there!

First, we recommend making sure to allow enough time for the decision-making process.  A bare minimum of two hours will be needed, very likely more.

Second, have plots of any interactions handy.

Third, before you conduct the decision-making “for real” on your own data, consider conducting a realistic practice exercise with your team using one of the data sets and accompanying documentation we provide for this purpose.  These are artificial data, so no need to be concerned about obtaining IRB approval.  This exercise may be a useful warm-up before the real thing.

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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