I am a junior scientist who does not yet have any training in MOST, but see intervention optimization as essential to my research in the coming years. Do you think it’s possible to obtaining training in MOST via a K01 or similar?


Definitely!  There have been a number of K awards with similar objectives funded through several of the institutes within the National Institutes of Health.  You can use the National Institutes of Health RePORTER to search for them (hint: use multiphase as a keyword).

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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