Featured Event

Registration Now Open

Intervention Optimization: Science and Practice, Present and Future Registration for the May 2026 Conference on Intervention Optimization is now open - learn more and sign up here. May 18-20, 2026; Maryland

CADIO Academy

New Asynchronous Course

We're excited to announce that our next asynchronous course is now live! Developed by Linda M. Collins and Jillian Strayhorn, "Introduction to Fractional Factorial Experimental Designs" is available for free at the link below and assumes completion of either "MOST From a Conceptual Perspective" or "MOST from a Methodological Perspective." Course Link: https://bit.ly/fractionalfact

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...

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