Should I apply for funding to support all three phases of MOST?


Yes, but it is probably unrealistic to expect that funding can be obtained in a single grant.  The approach that we have observed seems to have the highest probability of success is to start by obtaining local pilot funding or a small National Institutes of Health grant to conduct the preparation phase, including pilot testing the optimization trial.  Having completed this work puts the applicant in a strong position to apply for National Institutes of Health R01 or similar funding to conduct optimization and evaluation trials.  However, many R01s have been awarded to investigators who had not yet completed the entire preparation phase.

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Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...


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