Featured Event

May 2026 Conference on Intervention Optimization

Intervention Optimization: Science and Practice, Present and Future CADIO and the Data Science for Dynamic Intervention Decision-Making Center (d3center) are excited to announce the first academic conference on intervention optimization! Click this post to save the date and sign up for more information. May 18-20, 2026; Maryland

Featured Publication

Intervention Optimization’s 20th Anniversary

From the desk of Director Linda Collins: "In this commentary, I reflect on the evolution of intervention optimization from that first publication to today, and on what the future could hold if the intervention science field continues to adopt the optimization paradigm." Read more in Annals of Behavioral Medicine.

All News

Dear Caddy…

Dear Caddy, I am considering conducting a factorial optimization RCT. However, I’ve been told that the factors have to be independent. Is this true? It seems to me that it would be pretty unusual for...

Dear Caddy…

Dear Caddy, How would you respond if, in a summary statement, one of the reviewers said that MOST can no longer be considered innovative? Sincerely, Asking for a Friend Dear Asking, This comes down to...

Further Learning

Whether you are looking for additional support as you prepare a grant proposal involving MOST or practical information helpful in managing your optimization trial, this section provides resources for a deeper dive into intervention optimization.

REDCap with Most

The goal of this manual is to show how one might setup a REDCap project to support a research study with multiple conditions, such as factorial experiments common in the Multiphase Optimization Strategy (MOST) framework.

Informal introduction to factorial experimental designs

The purpose of this page is to clarify some concepts, notation, and terminology related to factorial experimental designs, and to compare and contrast factorial experiments to randomized controlled trials (RCTs). A more in-depth introduction can...

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